Muscarinic Receptors as Model Targets and Antitargets for Structure-Based Ligand Discovery

G protein–coupled receptors (GPCRs) regulate virtually all aspects of human physiology and represent an important class of therapeutic drug targets. Many GPCR-targeted drugs resemble endogenous agonists, often resulting in poor selectivity among receptor subtypes and restricted pharmacologic profile...

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Autori principali: Kruse, Andrew C., Weiss, Dahlia R., Rossi, Mario, Hu, Jianxin, Hu, Kelly, Eitel, Katrin, Gmeiner, Peter, Wess, Jürgen, Kobilka, Brian K., Shoichet, Brian K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781386/
https://ncbi.nlm.nih.gov/pubmed/23887926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087551
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