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Muscarinic Receptors as Model Targets and Antitargets for Structure-Based Ligand Discovery
G protein–coupled receptors (GPCRs) regulate virtually all aspects of human physiology and represent an important class of therapeutic drug targets. Many GPCR-targeted drugs resemble endogenous agonists, often resulting in poor selectivity among receptor subtypes and restricted pharmacologic profile...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3781386/ https://ncbi.nlm.nih.gov/pubmed/23887926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087551 |
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