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Selectivity Challenges in Docking Screens for GPCR Targets and Antitargets
[Image: see text] To investigate large library docking’s ability to find molecules with joint activity against on-targets and selectivity versus antitargets, the dopamine D(2) and serotonin 5-HT(2A) receptors were targeted, seeking selectivity against the histamine H(1) receptor. In a second campaig...
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| Pubblicato in: | J Med Chem |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2018
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6105036/ https://ncbi.nlm.nih.gov/pubmed/29990431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00718 |
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