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Discovery of new GPCR ligands to illuminate new biology

Although a plurality of drugs target G-protein-coupled receptors (GPCRs), most have emerged from classical medicinal chemistry and pharmacology programs and resemble one another structurally and functionally. Though effective, these drugs are often promiscuous. With the realization that GPCRs signal...

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Bibliografiske detaljer
Udgivet i:Nat Chem Biol
Main Authors: Roth, Bryan L, Irwin, John J, Shoichet, Brian K
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835362/
https://ncbi.nlm.nih.gov/pubmed/29045379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2490
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