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Discovery of new GPCR ligands to illuminate new biology

Although a plurality of drugs target G-protein-coupled receptors (GPCRs), most have emerged from classical medicinal chemistry and pharmacology programs and resemble one another structurally and functionally. Though effective, these drugs are often promiscuous. With the realization that GPCRs signal...

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Pubblicato in:Nat Chem Biol
Autori principali: Roth, Bryan L, Irwin, John J, Shoichet, Brian K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835362/
https://ncbi.nlm.nih.gov/pubmed/29045379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2490
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