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How ligands illuminate GPCR molecular pharmacology

G protein-coupled receptors (GPCRs), which are modulated by a variety of endogenous and synthetic ligands, represent the largest family of druggable targets in the human genome. Recent structural and molecular studies have both transformed and expanded classical concepts of receptor pharmacology and...

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Foilsithe in:Cell
Main Authors: Wacker, Daniel, Stevens, Raymond C., Roth, Bryan L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560499/
https://ncbi.nlm.nih.gov/pubmed/28753422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.009
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