Allosteric sodium in class A GPCR signaling

Despite their functional and structural diversity, G protein-coupled receptors (GPCRs) share a common mechanism of signal transduction via conformational changes in the seven-transmembrane (7TM) helical domain. New major insights into this mechanism come from the recent crystallographic discoveries...

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Autors principals: Katritch, Vsevolod, Fenalti, Gustavo, Abola, Enrique E., Roth, Bryan L., Cherezov, Vadim, Stevens, Raymond C.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106411/
https://ncbi.nlm.nih.gov/pubmed/24767681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2014.03.002
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