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Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling
Sodium ions are endogenous allosteric modulators of many G protein-coupled receptors (GPCRs). Mutation of key residues in the sodium binding motif causes a striking effect on G protein signaling. We report the crystal structures of agonist complexes for two variants in the first sodium coordination...
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| Publicado no: | Structure |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5810373/ https://ncbi.nlm.nih.gov/pubmed/29395784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.12.013 |
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