Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions()

Pharmacological responses of G protein-coupled receptors (GPCRs) can be fine-tuned by allosteric modulators. Structural studies of such effects have been limited due to the medium resolution of GPCR structures. We re-engineered the human A(2A) adenosine receptor by replacing its third intracellular...

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Bibliographic Details
Main Authors:	Liu, Wei, Chun, Eugene, Thompson, Aaron A., Chubukov, Pavel, Xu, Fei, Katritch, Vsevolod, Han, Gye Won, Roth, Christopher B., Heitman, Laura H., IJzerman, Adriaan P., Cherezov, Vadim, Stevens, Raymond C.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3399762/ https://ncbi.nlm.nih.gov/pubmed/22798613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1219218
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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions()

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