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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions()
Pharmacological responses of G protein-coupled receptors (GPCRs) can be fine-tuned by allosteric modulators. Structural studies of such effects have been limited due to the medium resolution of GPCR structures. We re-engineered the human A(2A) adenosine receptor by replacing its third intracellular...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3399762/ https://ncbi.nlm.nih.gov/pubmed/22798613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1219218 |
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