Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions()

Pharmacological responses of G protein-coupled receptors (GPCRs) can be fine-tuned by allosteric modulators. Structural studies of such effects have been limited due to the medium resolution of GPCR structures. We re-engineered the human A(2A) adenosine receptor by replacing its third intracellular...

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Autores principales: Liu, Wei, Chun, Eugene, Thompson, Aaron A., Chubukov, Pavel, Xu, Fei, Katritch, Vsevolod, Han, Gye Won, Roth, Christopher B., Heitman, Laura H., IJzerman, Adriaan P., Cherezov, Vadim, Stevens, Raymond C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399762/
https://ncbi.nlm.nih.gov/pubmed/22798613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1219218
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