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Sodium Ion Binding Pocket Mutations and Adenosine A(2A) Receptor Function
Recently we identified a sodium ion binding pocket in a high-resolution structure of the human adenosine A(2A) receptor. In the present study we explored this binding site through site-directed mutagenesis and molecular dynamics simulations. Amino acids in the pocket were mutated to alanine, and the...
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| Publicado no: | Mol Pharmacol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6067640/ https://ncbi.nlm.nih.gov/pubmed/25473121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095737 |
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