Ligand Binding and Subtype Selectivity of the Human A(2A) Adenosine Receptor: IDENTIFICATION AND CHARACTERIZATION OF ESSENTIAL AMINO ACID RESIDUES

The crystal structure of the human A(2A) adenosine receptor bound to the A(2A) receptor-specific antagonist, ZM241385, was recently determined at 2.6-Å resolution. Surprisingly, the antagonist binds in an extended conformation, perpendicular to the plane of the membrane, and indicates a number of in...

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Bibliographische Detailangaben
Hauptverfasser: Jaakola, Veli-Pekka, Lane, J. Robert, Lin, Judy Y., Katritch, Vsevolod, IJzerman, Adriaan P., Stevens, Raymond C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Membrane Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857108/
https://ncbi.nlm.nih.gov/pubmed/20147292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096974
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