Optimization of Adenosine 5′-Carboxamide Derivatives as Adenosine Receptor Agonists Using Structure-Based Ligand Design and Fragment Screening

[Image: see text] Structures of G protein-coupled receptors (GPCRs) have a proven utility in the discovery of new antagonists and inverse agonists modulating signaling of this important family of clinical targets. Applicability of active-state GPCR structures to virtual screening and rational optimi...

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Main Authors: Tosh, Dilip K., Phan, Khai, Gao, Zhan-Guo, Gakh, Andrei A., Xu, Fei, Deflorian, Francesca, Abagyan, Ruben, Stevens, Raymond C., Jacobson, Kenneth A., Katritch, Vsevolod
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479662/
https://ncbi.nlm.nih.gov/pubmed/22486652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300095s
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