Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions

gan Tosh, Dilip K., Paoletta, Silvia, Phan, Khai, Gao, Zhan-Guo, Jacobson, Kenneth A.
Cyhoeddwyd 2012

Structure–Activity Relationships and Molecular Modeling of 1,2,4-Triazoles as Adenosine Receptor Antagonists

gan Carlsson, Jens, Tosh, Dilip K., Phan, Khai, Gao, Zhan-Guo, Jacobson, Kenneth A.
Cyhoeddwyd 2012

Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element

gan Tosh, Dilip K., Phan, Khai, Deflorian, Francesca, Wei, Qiang, Gao, Zhan-Guo, Jacobson, Kenneth A.
Cyhoeddwyd 2011

Limits of Ligand Selectivity from Docking to Models: In Silico Screening for A(1) Adenosine Receptor Antagonists

gan Kolb, Peter, Phan, Khai, Gao, Zhan-Guo, Marko, Adam C., Sali, Andrej, Jacobson, Kenneth A.
Cyhoeddwyd 2012

Click Modification in the N(6) Region of A(3) Adenosine Receptor-Selective Carbocyclic Nucleosides for Dendrimeric Tethering that Preserves Pharmacophore Recognition

gan Tosh, Dilip K., Phan, Khai, Deflorian, Francesca, Wei, Qiang, Yoo, Lena S., Gao, Zhan-Guo, Jacobson, Kenneth A.
Cyhoeddwyd 2012

Structural Sweet Spot for A(1) Adenosine Receptor Activation by Truncated (N)- Methanocarba Nucleosides: Receptor Docking and Potent Anticonvulsant Activity

gan Tosh, Dilip K., Paoletta, Silvia, Deflorian, Francesca, Phan, Khai, Moss, Steven M., Gao, Zhan-Guo, Jiang, Xiaohui, Jacobson, Kenneth A.
Cyhoeddwyd 2012

Evaluation of Molecular Modeling of Agonist Binding in Light of the Crystallographic Structure of an Agonist-Bound A(2A) Adenosine Receptor

gan Deflorian, Francesca, Kumar, T. Santhosh, Phan, Khai, Gao, Zhan-Guo, Xu, Fei, Wu, Huixian, Katritch, Vsevolod, Stevens, Raymond C., Jacobson, Kenneth A.
Cyhoeddwyd 2011

Structure-Guided Design of A(3) Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions

gan Tosh, Dilip K., Deflorian, Francesca, Phan, Khai, Gao, Zhan-Guo, Wan, Tina C., Gizewski, Elizabeth, Auchampach, John A., Jacobson, Kenneth A.
Cyhoeddwyd 2012

Stereoselective Synthesis of Truncated 3’-Aminoadenosine Derivatives and their Binding Affinity at the A(3) Adenosine Receptor

gan Choi, Mun Ju, Chandra, Goirish, Lee, Hyuk Woo, Hou, Xiyan, Choi, Won Jun, Phan, Khai, Jacobson, Kenneth A., Jeong, Lak Shin
Cyhoeddwyd 2011

Novel Fluorescent Antagonist as a Molecular Probe in A(3) Adenosine Receptor Binding Assays Using Flow Cytometry

gan Kozma, Eszter, Kumar, T. Santhosh, Federico, Stephanie, Phan, Khai, Balasubramanian, Ramachandran, Gao, Zhan-Guo, Paoletta, Silvia, Moro, Stefano, Spalluto, Giampiero, Jacobson, Kenneth A.
Cyhoeddwyd 2012

Anti-ischemic effects of multivalent dendrimeric A(3) adenosine receptor agonists in cultured cardiomyocytes and in the isolated rat heart

gan Chanyshev, Bella, Shainberg, Asher, Isak, Ahuva, Litinsky, Alexandra, Chepurko, Yelena, Tosh, Dilip K., Phan, Khai, Gao, Zhan-Guo, Hochhauser, Edith, Jacobson, Kenneth A.
Cyhoeddwyd 2011

Molecular Probes for the A(2A) Adenosine Receptor Based on a Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine Scaffold

gan Kumar, T. Santhosh, Mishra, Shilpi, Deflorian, Francesca, Yoo, Lena S., Phan, Khai, Kecskés, Miklos, Szabo, Angela, Shinkre, Bidhan, Gao, Zhan-Guo, Trenkle, William, Jacobson, Kenneth A.
Cyhoeddwyd 2010

Modulation of G protein-coupled adenosine receptors by strategically functionalized agonists and antagonists immobilized on gold nanoparticles

gan Jayasekara, P. Suresh, Phan, Khai, Tosh, Dilip K., Kumar, T. Santhosh, Moss, Steven M., Zhang, Guofeng, Barchi, Joseph J., Gao, Zhan-Guo, Jacobson, Kenneth A.
Cyhoeddwyd 2012

Optimization of Adenosine 5′-Carboxamide Derivatives as Adenosine Receptor Agonists Using Structure-Based Ligand Design and Fragment Screening

gan Tosh, Dilip K., Phan, Khai, Gao, Zhan-Guo, Gakh, Andrei A., Xu, Fei, Deflorian, Francesca, Abagyan, Ruben, Stevens, Raymond C., Jacobson, Kenneth A., Katritch, Vsevolod
Cyhoeddwyd 2012

Programmable Nanoscaffolds That Control Ligand Display to a G-Protein-Coupled Receptor in Membranes To Allow Dissection of Multivalent Effects

gan Dix, Andrew V., Moss, Steven M., Phan, Khai, Hoppe, Travis, Paoletta, Silvia, Kozma, Eszter, Gao, Zhan-Guo, Durell, Stewart R., Jacobson, Kenneth A., Appella, Daniel H.
Cyhoeddwyd 2014

Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N(6)-Substituted-(N)-Methanocarba-nucleosides as A(3) Adenosine Receptor Antagonists and P...

gan Nayak, Akshata, Chandra, Girish, Hwang, Inah, Kim, Kyunglim, Hou, Xiyan, Kim, Hea Ok, Sahu, Pramod K., Roy, Kuldeep K., Yoo, Jakyung, Lee, Yoonji, Cui, Minghua, Choi, Sun, Moss, Steven M., Phan, Khai, Gao, Zhan-Guo, Ha, Hunjoo, Jacobson, Kenneth A., Jeong, Lak Shin
Cyhoeddwyd 2014

Structure-Activity Relationships of Truncated C2- or C8-Substituted Adenosine Derivatives as Dual Acting A(2A) and A(3) Adenosine Receptor Ligands

gan Hou, Xiyan, Majik, Mahesh S., Kim, Kyunglim, Pyee, Yuna, Lee, Yoonji, Alexander, Varughese, Chung, Hwa-Jin, Lee, Hyuk Woo, Chandra, Girish, Lee, Jin Hee, Park, Seul-gi, Choi, Won Jun, Kim, Hea Ok, Phan, Khai, Gao, Zhan-Guo, Jacobson, Kenneth A., Choi, Sun, Lee, Sang Kook, Jeong, Lak Shin
Cyhoeddwyd 2011