Structural Sweet Spot for A(1) Adenosine Receptor Activation by Truncated (N)- Methanocarba Nucleosides: Receptor Docking and Potent Anticonvulsant Activity

A(1) adenosine receptor (AR) agonists display antiischemic and antiepileptic neuroprotective activity, but peripheral cardiovascular side effects impeded their development. SAR study of N(6)-cycloalkylmethyl 4′-truncated (N)-methanocarba-adenosines identified 10 (MRS5474, N(6)-dicyclopropylmethyl, K...

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Detalhes bibliográficos
Main Authors: Tosh, Dilip K., Paoletta, Silvia, Deflorian, Francesca, Phan, Khai, Moss, Steven M., Gao, Zhan-Guo, Jiang, Xiaohui, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463139/
https://ncbi.nlm.nih.gov/pubmed/22921089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300965a
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