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Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element
[Image: see text] A(1) adenosine receptor (AR) agonists are neuroprotective, cardioprotective, and anxiolytic. (N)-Methanocarba adenine nucleosides designed to bind to human A(1)AR were truncated to eliminate 5′-CH(2)OH. This modification previously converted A(3)AR agonists into antagonists, but th...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical Society
2011
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3156476/ https://ncbi.nlm.nih.gov/pubmed/21858244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200114q |
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