Загрузка...
Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A(3) Adenosine Receptors: Affinity Enhancement by N(6)-(2-Phenylethyl) Substitution
Dopamine-derived N(6)-substituents, compared to N(6)-(2-phenylethyl), in truncated (N)-methanocarba (bicyclo[3.1.0]hexyl) adenosines favored high A(3) adenosine receptor (AR) affinity/selectivity, e.g. C2-phenylethynyl analogue 15 (MRS7591, K(i) 10.9/17.8 nM, at human/mouse A(3)AR). 15 was a partial...
Сохранить в:
| Опубликовано в: : | J Med Chem |
|---|---|
| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7443318/ https://ncbi.nlm.nih.gov/pubmed/32271569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00235 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|