Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A(3) Adenosine Receptor Agonists

[Image: see text] Purine (N)-methanocarba-5′-N-alkyluronamidoriboside A(3) adenosine receptor (A(3)AR) agonists lacking an exocyclic amine resulted from an unexpected reaction during a Sonogashira coupling and subsequent aminolysis. Because the initial C6-Me and C6-styryl derivatives had unexpectedl...

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Pubblicato in:J Med Chem
Autori principali: Tosh, Dilip K., Ciancetta, Antonella, Warnick, Eugene, O’Connor, Robert, Chen, Zhoumou, Gizewski, Elizabeth, Crane, Steven, Gao, Zhan-Guo, Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2016
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970510/
https://ncbi.nlm.nih.gov/pubmed/26890707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01998
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