Methanocarba Analogues of Purine Nucleosides as Potent and Selective Adenosine Receptor Agonists

Adenosine receptor agonists have cardioprotective, cerebroprotective, and antiinflammatory properties. We report that a carbocyclic modification of the ribose moiety incorporating ring constraints is a general approach for the design of A(1) and A(3) receptor agonists having favorable pharmacodynami...

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Bibliographic Details
Main Authors: Jacobson, Kenneth A., Ji, Xiao-duo, Li, An-Hu, Melman, Neli, Siddiqui, Maqbool A., Shin, Kye-Jung, Marquez, Victor E., Ravi, R. Gnana
Format: Artigo
Language:Inglês
Published: 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471159/
https://ncbi.nlm.nih.gov/pubmed/10841798
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