Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists

[Image: see text] While screening off-target effects of rigid (N)-methanocarba-adenosine 5′-methylamides as A(3) adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). In an effort to increase OR and decrease AR affinity by str...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Tosh, Dilip K., Ciancetta, Antonella, Mannes, Philip, Warnick, Eugene, Janowsky, Aaron, Eshleman, Amy J., Gizewski, Elizabeth, Brust, Tarsis F., Bohn, Laura M., Auchampach, John A., Gao, Zhan-Guo, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6210068/
https://ncbi.nlm.nih.gov/pubmed/30411015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01237
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