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Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists
[Image: see text] While screening off-target effects of rigid (N)-methanocarba-adenosine 5′-methylamides as A(3) adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). In an effort to increase OR and decrease AR affinity by str...
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| 出版年: | ACS Omega |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical Society
2018
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| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6210068/ https://ncbi.nlm.nih.gov/pubmed/30411015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01237 |
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