Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists

[Image: see text] While screening off-target effects of rigid (N)-methanocarba-adenosine 5′-methylamides as A(3) adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). In an effort to increase OR and decrease AR affinity by str...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:ACS Omega
Asıl Yazarlar: Tosh, Dilip K., Ciancetta, Antonella, Mannes, Philip, Warnick, Eugene, Janowsky, Aaron, Eshleman, Amy J., Gizewski, Elizabeth, Brust, Tarsis F., Bohn, Laura M., Auchampach, John A., Gao, Zhan-Guo, Jacobson, Kenneth A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2018
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6210068/
https://ncbi.nlm.nih.gov/pubmed/30411015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01237
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller