載入...
Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT(2B)/5HT(2C) Serotonin Receptor Antagonists
Adenosine derivatives developed to activate adenosine receptors (ARs) revealed µM activity at serotonin 5HT(2B) and 5HT(2C) receptors (5HTRs). We explored the SAR at 5HT(2)Rs and modeled receptor interactions in order to optimize affinity and simultaneously reduce AR affinity. Depending on N(6) subs...
Na minha lista:
| 發表在: | J Med Chem |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2016
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5201133/ https://ncbi.nlm.nih.gov/pubmed/27933810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01183 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|