Methanocarba ring as a ribose modification in ligands of G protein-coupled purine and pyrimidine receptors: synthetic approaches

Por Tosh, Dilip K., Jacobson, Kenneth A.
Publicado no Medchemcomm (2013)

Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

Por Paoletta, Silvia, Tosh, Dilip K., Salvemini, Daniela, Jacobson, Kenneth A.
Publicado em 2014

Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A(3) adenosine receptor agonist that protects against chronic neuropathic pain

Por Tosh, Dilip K., Padia, Janak, Salvemini, Daniela, Jacobson, Kenneth A.
Publicado no Purinergic Signal (2015)

Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine

Por Janowsky, Aaron, Tosh, Dilip K., Eshleman, Amy J., Jacobson, Kenneth A.
Publicado no J Pharmacol Exp Ther (2016)

GPCR Ligand Dendrimer (GLiDe) Conjugates: Adenosine Receptor Interactions of a Series of Multivalent Xanthine Antagonists

Por Kecskés, Angela, Tosh, Dilip K., Wei, Qiang, Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado em 2011

Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions

Por Tosh, Dilip K., Paoletta, Silvia, Phan, Khai, Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado em 2012

Structure–Activity Relationships and Molecular Modeling of 1,2,4-Triazoles as Adenosine Receptor Antagonists

Por Carlsson, Jens, Tosh, Dilip K., Phan, Khai, Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado em 2012

Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element

Por Tosh, Dilip K., Phan, Khai, Deflorian, Francesca, Wei, Qiang, Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado em 2011

Characterization by Flow Cytometry of Fluorescent, Selective Agonist Probes of the A(3) Adenosine Receptor

Por Kozma, Eszter, Gizewski, Elizabeth T., Tosh, Dilip K., Squarcialupi, Lucia, Auchampach, John A., Jacobson, Kenneth A.
Publicado em 2013

Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT(2B)/5HT(2C) Serotonin Receptor Antagonists

Por Tosh, Dilip K., Ciancetta, Antonella, Warnick, Eugene, Crane, Steven, Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado no J Med Chem (2016)

Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A(3 )adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts

Por Wan, Tina C, Tosh, Dilip K, Du, Lili, Gizewski, Elizabeth T, Jacobson, Kenneth A, Auchampach, John A
Publicado em 2011

Functionalized Congeners of A(3) Adenosine Receptor-Selective Nucleosides Containing a Bicyclo[3.1.0]hexane Ring System

Por Tosh, Dilip K., Chinn, Moshe, Ivanov, Andrei A., Klutz, Athena M., Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado em 2009

Click Modification in the N(6) Region of A(3) Adenosine Receptor-Selective Carbocyclic Nucleosides for Dendrimeric Tethering that Preserves Pharmacophore Recognition

Por Tosh, Dilip K., Phan, Khai, Deflorian, Francesca, Wei, Qiang, Yoo, Lena S., Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado em 2012

Medicinal Chemistry of the A(3) Adenosine Receptor: Agonists, Antagonists, and Receptor Engineering

Por Jacobson, Kenneth A., Klutz, Athena M., Tosh, Dilip K., Ivanov, Andrei A., Preti, Delia, Baraldi, Pier Giovanni
Publicado em 2009

2-Dialkynyl Derivatives of (N)-Methanocarba Nucleosides: “Clickable” A(3) Adenosine Receptor-Selective Agonists

Por Tosh, Dilip K., Chinn, Moshe, Yoo, Lena S., Kang, Dong Wook, Luecke, Hans, Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado em 2009

Controlling murine and rat chronic pain through A(3) adenosine receptor activation

Por Chen, Zhoumou, Janes, Kali, Chen, Collin, Doyle, Tim, Bryant, Leesa, Tosh, Dilip K., Jacobson, Kenneth A., Salvemini, Daniela
Publicado em 2012

Extended N(6) Substitution of Rigid C2-Arylethynyl Nucleosides for Exploring the Role of Extracellular Loops in Ligand Recognition at the A(3) Adenosine Receptor

Por Tosh, Dilip K., Paoletta, Silvia, Chen, Zhoumou, Moss, Steven M., Gao, Zhan-Guo, Salvemini, Daniela, Jacobson, Kenneth A.
Publicado em 2014

Structural Sweet Spot for A(1) Adenosine Receptor Activation by Truncated (N)- Methanocarba Nucleosides: Receptor Docking and Potent Anticonvulsant Activity

Por Tosh, Dilip K., Paoletta, Silvia, Deflorian, Francesca, Phan, Khai, Moss, Steven M., Gao, Zhan-Guo, Jiang, Xiaohui, Jacobson, Kenneth A.
Publicado em 2012

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors()

Por Jacobson, Kenneth A., Gao, Zhan-Guo, Paoletta, Silvia, Kiselev, Evgeny, Chakraborty, Saibal, Jayasekara, P. Suresh, Balasubramanian, Ramachandran, Tosh, Dilip K.
Publicado no Comput Struct Biotechnol J (2014)

Structure-Guided Design of A(3) Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions

Por Tosh, Dilip K., Deflorian, Francesca, Phan, Khai, Gao, Zhan-Guo, Wan, Tina C., Gizewski, Elizabeth, Auchampach, John A., Jacobson, Kenneth A.
Publicado em 2012