Structure-Guided Design of A(3) Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions

(N)-Methanocarba adenosine 5′-methyluronamides containing known A(3) AR (adenosine receptor)-enhancing modifications, i.e. 2-(arylethynyl)adenine and N(6)-methyl or N(6)-(3-substituted-benzyl), were nanomolar full agonists of human (h) A(3)AR and highly selective (K(i) ~0.6 nM, N(6)-methyl 2-(haloph...

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Detalhes bibliográficos
Main Authors: Tosh, Dilip K., Deflorian, Francesca, Phan, Khai, Gao, Zhan-Guo, Wan, Tina C., Gizewski, Elizabeth, Auchampach, John A., Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371665/
https://ncbi.nlm.nih.gov/pubmed/22559880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300396n
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