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Functionalized Congeners of A(3) Adenosine Receptor-Selective Nucleosides Containing a Bicyclo[3.1.0]hexane Ring System

(N)-Methanocarba nucleosides containing bicyclo[3.1.0]hexane replacement of the ribose ring previously demonstrated selectivity as A(3) adenosine receptor (AR) agonists (5′-uronamides) or antagonists (5′-truncated). Here, these two series were modified in parallel at the adenine C2 position. N(6)-3-...

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Detalhes bibliográficos
Main Authors: Tosh, Dilip K., Chinn, Moshe, Ivanov, Andrei A., Klutz, Athena M., Gao, Zhan-Guo, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109436/
https://ncbi.nlm.nih.gov/pubmed/19499950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900426g
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