Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions

[Image: see text] C2-Arylethynyladenosine-5′-N-methyluronamides containing a bicyclo[3.1.0]hexane [(N)-methanocarba] ring are selective A(3) adenosine receptor (AR) agonists. Similar 4′-truncated C2-arylethynyl-(N)-methanocarba nucleosides containing alkyl or alkylaryl groups at the N(6) position we...

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Détails bibliographiques
Auteurs principaux: Tosh, Dilip K., Paoletta, Silvia, Phan, Khai, Gao, Zhan-Guo, Jacobson, Kenneth A.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2012
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491360/
https://ncbi.nlm.nih.gov/pubmed/23145215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300107e
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