Computational studies to predict or explain GPCR polypharmacology

Por Jacobson, Kenneth A., Costanzi, Stefano, Paoletta, Silvia
Publicado no Trends Pharmacol Sci (2014)

Molecular modeling of the human P2Y(14) receptor: A template for structure-based design of selective agonist ligands

Por Trujillo, Kevin, Paoletta, Silvia, Kiselev, Evgeny, Jacobson, Kenneth A.
Publicado no Bioorg Med Chem (2015)

Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

Por Paoletta, Silvia, Tosh, Dilip K., Salvemini, Daniela, Jacobson, Kenneth A.
Publicado em 2014

Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions

Por Tosh, Dilip K., Paoletta, Silvia, Phan, Khai, Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado em 2012

Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A(2A) Adenosine Receptor

Por Moss, Steven M., Jayasekara, P. Suresh, Paoletta, Silvia, Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado em 2014

Synthesis and Evaluation of N(6)-Substituted Apioadenosines as Potential Adenosine A(3) Receptor Modulators

Por Toti, Kiran S., Moss, Steven M., Paoletta, Silvia, Gao, Zhan-Guo, Jacobson, Kenneth A., Van Calenbergh, Serge
Publicado em 2014

Fluorescent Ligands for Adenosine Receptors

Por Kozma, Eszter, Jayasekara, P Suresh, Squarcialupi, Lucia, Paoletta, Silvia, Moro, Stefano, Federico, Stephanie, Spalluto, Giampiero, Jacobson, Kenneth A.
Publicado em 2012

Extended N(6) Substitution of Rigid C2-Arylethynyl Nucleosides for Exploring the Role of Extracellular Loops in Ligand Recognition at the A(3) Adenosine Receptor

Por Tosh, Dilip K., Paoletta, Silvia, Chen, Zhoumou, Moss, Steven M., Gao, Zhan-Guo, Salvemini, Daniela, Jacobson, Kenneth A.
Publicado em 2014

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function

Por Jacobson, Kenneth A., Paoletta, Silvia, Katritch, Vsevolod, Wu, Beili, Gao, Zhan-Guo, Zhao, Qiang, Stevens, Raymond C., Kiselev, Evgeny
Publicado no Mol Pharmacol (2015)

Structural Sweet Spot for A(1) Adenosine Receptor Activation by Truncated (N)- Methanocarba Nucleosides: Receptor Docking and Potent Anticonvulsant Activity

Por Tosh, Dilip K., Paoletta, Silvia, Deflorian, Francesca, Phan, Khai, Moss, Steven M., Gao, Zhan-Guo, Jiang, Xiaohui, Jacobson, Kenneth A.
Publicado em 2012

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors()

Por Jacobson, Kenneth A., Gao, Zhan-Guo, Paoletta, Silvia, Kiselev, Evgeny, Chakraborty, Saibal, Jayasekara, P. Suresh, Balasubramanian, Ramachandran, Tosh, Dilip K.
Publicado no Comput Struct Biotechnol J (2014)

Identification of a new dysfunctional platelet P2Y(12) receptor variant associated with bleeding diathesis

Por Lecchi, Anna, Razzari, Cristina, Paoletta, Silvia, Dupuis, Arnaud, Nakamura, Lea, Ohlmann, Philippe, Gachet, Christian, Jacobson, Kenneth A., Zieger, Barbara, Cattaneo, Marco
Publicado no Blood (2015)

Structure-Activity Analysis of Biased Agonism at the Human Adenosine A(3) Receptor

Por Baltos, Jo-Anne, Paoletta, Silvia, Nguyen, Anh T. N., Gregory, Karen J., Tosh, Dilip K., Christopoulos, Arthur, Jacobson, Kenneth A., May, Lauren T.
Publicado no Mol Pharmacol (2016)

Novel Fluorescent Antagonist as a Molecular Probe in A(3) Adenosine Receptor Binding Assays Using Flow Cytometry

Por Kozma, Eszter, Kumar, T. Santhosh, Federico, Stephanie, Phan, Khai, Balasubramanian, Ramachandran, Gao, Zhan-Guo, Paoletta, Silvia, Moro, Stefano, Spalluto, Giampiero, Jacobson, Kenneth A.
Publicado em 2012

Rigidified A(3) Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

Por Tosh, Dilip K., Crane, Steven, Chen, Zhoumou, Paoletta, Silvia, Gao, Zhan-Guo, Gizewski, Elizabeth, Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Publicado no ACS Med Chem Lett (2015)

Rational Design of Sulfonated A(3) Adenosine Receptor-Selective Nucleosides as Pharmacological Tools to Study Chronic Neuropathic Pain

Por Paoletta, Silvia, Tosh, Dilip K., Finley, Amanda, Gizewski, Elizabeth T., Moss, Steven M., Gao, Zhan-Guo, Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Publicado em 2013

In Vivo Phenotypic Screening for Treating Chronic Neuropathic Pain: Modification of C2-Arylethynyl Group of Conformationally Constrained A(3) Adenosine Receptor Agonists

Por Tosh, Dilip K., Finley, Amanda, Paoletta, Silvia, Moss, Steven M., Gao, Zhan-Guo, Gizewski, Elizabeth T., Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Publicado no J Med Chem (2014)

Photomodulation of G Protein-Coupled Adenosine Receptors by a Novel Light-Switchable Ligand

Por Bahamonde, María Isabel, Taura, Jaume, Paoletta, Silvia, Gakh, Andrei A., Chakraborty, Saibal, Hernando, Jordi, Fernández-Dueñas, Víctor, Jacobson, Kenneth A., Gorostiza, Pau, Ciruela, Francisco
Publicado em 2014

Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A(3) Adenosine Receptor Agonists

Por Tosh, Dilip K., Paoletta, Silvia, Chen, Zhoumou, Crane, Steven, Lloyd, John, Gao, Zhan-Guo, Gizewski, Elizabeth T., Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Publicado no Medchemcomm (2015)

Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A prelimina...

Por Pastorin, Giorgia, Federico, Stephanie, Paoletta, Silvia, Corradino, Marta, Cateni, Francesca, Cacciari, Barbara, Klotz, Karl-Norbert, Gao, Zhan-Guo, Jacobson, Kenneth A., Spalluto, Giampiero, Moro, Stefano
Publicado em 2010