Structure-Activity Analysis of Biased Agonism at the Human Adenosine A(3) Receptor

Biased agonism at G protein–coupled receptors (GPCRs) has significant implications for current drug discovery, but molecular determinants that govern ligand bias remain largely unknown. The adenosine A(3) GPCR (A(3)AR) is a potential therapeutic target for various conditions, including cancer, infla...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Baltos, Jo-Anne, Paoletta, Silvia, Nguyen, Anh T. N., Gregory, Karen J., Tosh, Dilip K., Christopoulos, Arthur, Jacobson, Kenneth A., May, Lauren T.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931866/
https://ncbi.nlm.nih.gov/pubmed/27136943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.103283
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