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Rigidified A(3) Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

[Image: see text] Substitution of rigidified A(3) adenosine receptor (AR) agonists with a 2-((5-chlorothiophen-2-yl)ethynyl) or a 2-(4-(5-chlorothiophen-2-yl)-1H-1,2,3-triazol-1-yl) group provides prolonged protection in a model of chronic neuropathic pain. These agonists contain a bicyclo[3.1.0]hex...

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Bibliografische gegevens
Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Tosh, Dilip K., Crane, Steven, Chen, Zhoumou, Paoletta, Silvia, Gao, Zhan-Guo, Gizewski, Elizabeth, Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2015
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499829/
https://ncbi.nlm.nih.gov/pubmed/26191370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00150
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