Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A(3) Adenosine Receptor Agonists

2-Arylethynyl derivatives of (N)-methanocarba adenosine 5′-uronamides are selective A(3)AR (adenosine receptor) agonists. Here we substitute a 1,2,3-triazol-1-yl linker in place of the rigid, linear ethynyl group to eliminate its potential metabolic liability. Docking of nucleosides containing possi...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Tosh, Dilip K., Paoletta, Silvia, Chen, Zhoumou, Crane, Steven, Lloyd, John, Gao, Zhan-Guo, Gizewski, Elizabeth T., Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517612/
https://ncbi.nlm.nih.gov/pubmed/26236460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00571F
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