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Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A(3) Adenosine Receptor Agonists
2-Arylethynyl derivatives of (N)-methanocarba adenosine 5′-uronamides are selective A(3)AR (adenosine receptor) agonists. Here we substitute a 1,2,3-triazol-1-yl linker in place of the rigid, linear ethynyl group to eliminate its potential metabolic liability. Docking of nucleosides containing possi...
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| Udgivet i: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4517612/ https://ncbi.nlm.nih.gov/pubmed/26236460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00571F |
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