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Design and in vivo activity of A(3) adenosine receptor agonist prodrugs
Prodrugs (MRS7422, MRS7476) of highly selective A(3) adenosine receptor (AR) agonists Cl-IB-MECA and MRS5698, respectively, were synthesized by succinylation of the 2′ and 3′ hydroxyl groups, and the parent, active drug was shown to be readily liberated upon incubation with liver esterases. The prod...
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| Publicado no: | Purinergic Signal |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Netherlands
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7524976/ https://ncbi.nlm.nih.gov/pubmed/32720036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-020-09715-0 |
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