Design and in vivo activity of A(3) adenosine receptor agonist prodrugs

Prodrugs (MRS7422, MRS7476) of highly selective A(3) adenosine receptor (AR) agonists Cl-IB-MECA and MRS5698, respectively, were synthesized by succinylation of the 2′ and 3′ hydroxyl groups, and the parent, active drug was shown to be readily liberated upon incubation with liver esterases. The prod...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Purinergic Signal
Egile Nagusiak: Suresh, R. Rama, Jain, Shanu, Chen, Zhoumou, Tosh, Dilip K., Ma, Yanling, Podszun, Maren C., Rotman, Yaron, Salvemini, Daniela, Jacobson, Kenneth A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer Netherlands 2020
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524976/
https://ncbi.nlm.nih.gov/pubmed/32720036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-020-09715-0
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