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Design and in vivo activity of A(3) adenosine receptor agonist prodrugs
Prodrugs (MRS7422, MRS7476) of highly selective A(3) adenosine receptor (AR) agonists Cl-IB-MECA and MRS5698, respectively, were synthesized by succinylation of the 2′ and 3′ hydroxyl groups, and the parent, active drug was shown to be readily liberated upon incubation with liver esterases. The prod...
Kaydedildi:
| Yayımlandı: | Purinergic Signal |
|---|---|
| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Springer Netherlands
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7524976/ https://ncbi.nlm.nih.gov/pubmed/32720036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-020-09715-0 |
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