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Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A(2A) Adenosine Receptor
[Image: see text] Adenosine receptors (ARs) are members of the G protein-coupled receptor (GPCR) superfamily and have shown much promise as therapeutic targets. We have used an agonist-bound A(2A)AR X-ray crystallographic structure to design a chemically reactive agonist for site-specific chemical m...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160753/ https://ncbi.nlm.nih.gov/pubmed/25221664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002486 |
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