Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A(3 )adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts

BACKGROUND: When stimulated by small molecular agonists, the A(3 )adenosine receptor (AR) mediates cardioprotective effects without inducing detrimental hemodynamic side effects. We have examined pharmacologically the protective properties of a multivalent dendrimeric conjugate of a nucleoside as a...

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Detalhes bibliográficos
Main Authors: Wan, Tina C, Tosh, Dilip K, Du, Lili, Gizewski, Elizabeth T, Jacobson, Kenneth A, Auchampach, John A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247180/
https://ncbi.nlm.nih.gov/pubmed/22039965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-11-11
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