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Polyamidoamine (PAMAM) Dendrimer Conjugates of “Clickable” Agonists of the A(3) Adenosine Receptor and Coactivation of the P2Y(14) Receptor by a Tethered Nucleotide
We previously synthesized a series of potent and selective A(3) adenosine receptor (AR) agonists (North-methanocarba nucleoside 5′-uronamides) containing dialkyne groups on extended adenine C2 substituents. We coupled the distal alkyne of a 2-octadiynyl nucleoside by Cu(I)-catalyzed “click” chemistr...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2845915/ https://ncbi.nlm.nih.gov/pubmed/20121074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc900473v |
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