Polyamidoamine (PAMAM) Dendrimer Conjugates of “Clickable” Agonists of the A(3) Adenosine Receptor and Coactivation of the P2Y(14) Receptor by a Tethered Nucleotide

We previously synthesized a series of potent and selective A(3) adenosine receptor (AR) agonists (North-methanocarba nucleoside 5′-uronamides) containing dialkyne groups on extended adenine C2 substituents. We coupled the distal alkyne of a 2-octadiynyl nucleoside by Cu(I)-catalyzed “click” chemistr...

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Detalhes bibliográficos
Main Authors: Tosh, Dilip K., Yoo, Lena S., Chinn, Moshe, Hong, Kunlun, Kilbey, S. Michael, Barrett, Matthew O., Fricks, Ingrid P., Harden, T. Kendall, Gao, Zhan-Guo, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845915/
https://ncbi.nlm.nih.gov/pubmed/20121074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc900473v
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