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Permeability of surface modified polyamidoamine (PAMAM) dendrimers across Caco-2 cell monolayers

Aim of this study was to prepare polyamine-conjugated PAMAM dendrimers and study their permeability across Caco-2 cell monolayers. Polyamines, namely, arginine and ornithine were conjugated to the amine terminals of the G4 PAMAM dendrimers by Fmoc synthesis. The apical-to-basolateral (AB) and basola...

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Detalhes bibliográficos
Main Authors: Yellepeddi, Venkata K., Pisal, Dipak S., Kumar, Ajay, Kaushik, Radhey S., Hildreth, Michael B., Guan, Xiangming, Palakurthi, Srinath
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266586/
https://ncbi.nlm.nih.gov/pubmed/17913410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2007.08.033
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