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Effect of polyamidoamine (PAMAM) dendrimers on the in vitro release of water-insoluble nifedipine from aqueous gels

The objective of this study was to determine the effect of ethylenediamine core PAMAM dendrimers, on the release of nifedipine suspended in aqueous gels and to correlate release to the increase in solubility afforded by the dendrimers. Drug release from aqueous 5% HPMC gels containing nifedipine (2%...

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Detalhes bibliográficos
Main Authors: Devarakonda, Bharathi, Li, Ning, de Villiers, Melgardt M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750397/
https://ncbi.nlm.nih.gov/pubmed/16354011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/pt060363
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