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2-Dialkynyl Derivatives of (N)-Methanocarba Nucleosides: “Clickable” A(3) Adenosine Receptor-Selective Agonists

We modified a series of (N)-methanocarba nucleoside 5 -uronamides to contain dialkyne groups on an extended adenine C2 substituent, as synthetic intermediates leading to potent and selective A(3) adenosine receptor (AR) agonists. The proximal alkyne was intended to promote receptor recognition, and...

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Главные авторы: Tosh, Dilip K., Chinn, Moshe, Yoo, Lena S., Kang, Dong Wook, Luecke, Hans, Gao, Zhan-Guo, Jacobson, Kenneth A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818678/
https://ncbi.nlm.nih.gov/pubmed/20036562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.12.018
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