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2-Dialkynyl Derivatives of (N)-Methanocarba Nucleosides: “Clickable” A(3) Adenosine Receptor-Selective Agonists

We modified a series of (N)-methanocarba nucleoside 5 -uronamides to contain dialkyne groups on an extended adenine C2 substituent, as synthetic intermediates leading to potent and selective A(3) adenosine receptor (AR) agonists. The proximal alkyne was intended to promote receptor recognition, and...

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Autors principals: Tosh, Dilip K., Chinn, Moshe, Yoo, Lena S., Kang, Dong Wook, Luecke, Hans, Gao, Zhan-Guo, Jacobson, Kenneth A.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818678/
https://ncbi.nlm.nih.gov/pubmed/20036562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.12.018
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