2-Dialkynyl Derivatives of (N)-Methanocarba Nucleosides: “Clickable” A(3) Adenosine Receptor-Selective Agonists

We modified a series of (N)-methanocarba nucleoside 5 -uronamides to contain dialkyne groups on an extended adenine C2 substituent, as synthetic intermediates leading to potent and selective A(3) adenosine receptor (AR) agonists. The proximal alkyne was intended to promote receptor recognition, and...

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Bibliographische Detailangaben
Hauptverfasser: Tosh, Dilip K., Chinn, Moshe, Yoo, Lena S., Kang, Dong Wook, Luecke, Hans, Gao, Zhan-Guo, Jacobson, Kenneth A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818678/
https://ncbi.nlm.nih.gov/pubmed/20036562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.12.018
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