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Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine

Thirty-two congeneric rigid adenine nucleoside derivatives containing a North (N)-methanocarba ribose substitution and a 2-arylethynyl group either enhanced (up to 760% of control) or inhibited [(125)I] methyl (1R,2S,3S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate (RTI-55) bind...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Janowsky, Aaron, Tosh, Dilip K., Eshleman, Amy J., Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809312/
https://ncbi.nlm.nih.gov/pubmed/26813929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229666
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