Design and in vivo Characterization of A(1) Adenosine Receptor Agonists in the Native Ribose and Conformationally-Constrained (N)-Methanocarba Series

(N)-Methanocarba ([3.1.0]bicyclohexyl) adenosines and corresponding ribosides were synthesized to identify novel A(1) adenosine receptor (A(1)AR) agonists for CNS or peripheral applications. Human and mouse AR binding was determined to assess the constrained ring system’s A(1)AR compatibility. N(6)-...

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Publicado no:J Med Chem
Main Authors: Tosh, Dilip K., Rao, Harsha, Bitant, Amelia, Salmaso, Veronica, Mannes, Philip, Lieberman, David I., Vaughan, Kelli L., Mattison, Julie A., Rothwell, Amy C., Auchampach, John A., Ciancetta, Antonella, Liu, Naili, Cui, Zhenzhong, Gao, Zhan-Guo, Reitman, Marc L., Gavrilova, Oksana, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467784/
https://ncbi.nlm.nih.gov/pubmed/30605331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01662
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