Design and in vivo Characterization of A(1) Adenosine Receptor Agonists in the Native Ribose and Conformationally-Constrained (N)-Methanocarba Series

(N)-Methanocarba ([3.1.0]bicyclohexyl) adenosines and corresponding ribosides were synthesized to identify novel A(1) adenosine receptor (A(1)AR) agonists for CNS or peripheral applications. Human and mouse AR binding was determined to assess the constrained ring system’s A(1)AR compatibility. N(6)-...

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Published in:J Med Chem
Main Authors: Tosh, Dilip K., Rao, Harsha, Bitant, Amelia, Salmaso, Veronica, Mannes, Philip, Lieberman, David I., Vaughan, Kelli L., Mattison, Julie A., Rothwell, Amy C., Auchampach, John A., Ciancetta, Antonella, Liu, Naili, Cui, Zhenzhong, Gao, Zhan-Guo, Reitman, Marc L., Gavrilova, Oksana, Jacobson, Kenneth A.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467784/
https://ncbi.nlm.nih.gov/pubmed/30605331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01662
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