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Structural Sweet Spot for A(1) Adenosine Receptor Activation by Truncated (N)- Methanocarba Nucleosides: Receptor Docking and Potent Anticonvulsant Activity
A(1) adenosine receptor (AR) agonists display antiischemic and antiepileptic neuroprotective activity, but peripheral cardiovascular side effects impeded their development. SAR study of N(6)-cycloalkylmethyl 4′-truncated (N)-methanocarba-adenosines identified 10 (MRS5474, N(6)-dicyclopropylmethyl, K...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463139/ https://ncbi.nlm.nih.gov/pubmed/22921089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300965a |
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