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Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N(6)-Substituted-(N)-Methanocarba-nucleosides as A(3) Adenosine Receptor Antagonists and Partial Agonists
[Image: see text] Truncated N(6)-substituted-(N)-methanocarba-adenosine derivatives with 2-hexynyl substitution were synthesized to examine parallels with corresponding 4′-thioadenosines. Hydrophobic N(6) and/or C2 substituents were tolerated in A(3)AR binding, but only an unsubstituted 6-amino grou...
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| Hoofdauteurs: | , , , , , , , , , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2014
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3954500/ https://ncbi.nlm.nih.gov/pubmed/24456490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4015313 |
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