Discovery of A New Human A(2A) Adenosine Receptor Agonist, Truncated 2-Hexynyl-4′-thioadenosine

[Image: see text] The truncated C2- and C8-substituted 4′-thioadenosine derivatives 4a−d were synthesized from d-mannose, using palladium-catalyzed cross-coupling reactions as key steps. In this study, an A(3) adenosine receptor (AR) antagonist, truncated 4′-thioadenosine derivative 3, was successfu...

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Detalhes bibliográficos
Main Authors: Hou, Xiyan, Kim, Hea Ok, Alexander, Varughese, Kim, Kyunglim, Choi, Sun, Park, Seul-gi, Lee, Jin Hee, Yoo, Lena S., Gao, Zhan-Guo, Jacobson, Kenneth A., Jeong, Lak Shin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030271/
https://ncbi.nlm.nih.gov/pubmed/21286238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1001823
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