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Synthesis of 2-Chloro-N(6)-Substituted-4′-thioadenosine-5′-N,N-dialkyluronamides as Potent and Selective A(3) Adenosine Receptor Antagonists

The highly selective A(3) receptor agonist, 4′-thio-Cl-IB-MECA was successfully converted into selective A(3) receptor antagonists by appending a second N-alkyl group on the 5′-uronamide position. This result indicates that the hydrogen bonding ability of the 5′-uronamide is essential for the confor...

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Detalhes bibliográficos
Main Authors: Choi, Won Jun, Lee, Hyuk Woo, Hou, Xiyan, Kim, Hea OK, Jacobson, Kenneth A., Jeong, Lak Shin
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748263/
https://ncbi.nlm.nih.gov/pubmed/18776545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nass/nrn326
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