Wird geladen...
Design and Synthesis of N(6)-Substituted-4′-thioadenosine-5′-uronamides As Potent and Selective Human A(3) Adenosine Receptor Agonists
On the basis of a bioisosteric rationale, 4′-thionucleoside analogues of IB-MECA, which is a potent and selective A(3) adenosine receptor agonist (AR), were synthesized from d-gulonic acid γ-lactone. The 4′-thio analogue (5h) of IB-MECA showed extremely high binding affinity (K(i) = 0.25 nM) at the...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2797373/ https://ncbi.nlm.nih.gov/pubmed/19879151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.10.011 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|