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Design and Synthesis of N(6)-Substituted-4′-thioadenosine-5′-uronamides As Potent and Selective Human A(3) Adenosine Receptor Agonists
On the basis of a bioisosteric rationale, 4′-thionucleoside analogues of IB-MECA, which is a potent and selective A(3) adenosine receptor agonist (AR), were synthesized from d-gulonic acid γ-lactone. The 4′-thio analogue (5h) of IB-MECA showed extremely high binding affinity (K(i) = 0.25 nM) at the...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2797373/ https://ncbi.nlm.nih.gov/pubmed/19879151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.10.011 |
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