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Structure-Activity Relationships of Truncated D- and L-4′-Thioadenosine Derivatives as Species-Independent A(3) Adenosine Receptor Antagonists(1)
Novel D- and L-4′-thioadenosine derivatives lacking the 4′-hydroxymethyl moiety were synthesized, starting from D-mannose and D-gulonic γ-lactone, respectively, as potent and selective species-independent A(3) adenosine receptor (AR) antagonists. Among the novel 4′-truncated 2-H nucleosides tested,...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616494/ https://ncbi.nlm.nih.gov/pubmed/18811138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8008647 |
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