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Structure-Activity Relationships of Truncated D- and L-4′-Thioadenosine Derivatives as Species-Independent A(3) Adenosine Receptor Antagonists(1)

Novel D- and L-4′-thioadenosine derivatives lacking the 4′-hydroxymethyl moiety were synthesized, starting from D-mannose and D-gulonic γ-lactone, respectively, as potent and selective species-independent A(3) adenosine receptor (AR) antagonists. Among the novel 4′-truncated 2-H nucleosides tested,...

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Bibliographische Detailangaben
Hauptverfasser: Jeong, Lak Shin, Pal, Shantanu, Choe, Seung Ah, Choi, Won Jun, Jacobson, Kenneth A., Gao, Zhan-Guo, Klutz, Athena M., Hou, Xiyan, Kim, Hea Ok, Lee, Hyuk Woo, Lee, Sang Kook, Tosh, Dilip K., Moon, Hyung Ryong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616494/
https://ncbi.nlm.nih.gov/pubmed/18811138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8008647
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