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Structure-Activity Relationships of Truncated Adenosine Derivatives as Highly Potent and Selective Human A(3) Adenosine Receptor Antagonists
On the basis of potent and selective binding affinity of truncated 4′-thioadenosine derivatives at the human A(3) adenosine receptor (AR), their bioisosteric 4′-oxo derivatives were designed and synthesized from commercially available 2,3-O-isopropylidene-d-erythrono lactone. The derivatives tested...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3578599/ https://ncbi.nlm.nih.gov/pubmed/19375920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.03.034 |
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