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Synthesis of 2-Chloro-N(6)-Substituted-4′-thioadenosine-5′-N,N-dialkyluronamides as Potent and Selective A(3) Adenosine Receptor Antagonists
The highly selective A(3) receptor agonist, 4′-thio-Cl-IB-MECA was successfully converted into selective A(3) receptor antagonists by appending a second N-alkyl group on the 5′-uronamide position. This result indicates that the hydrogen bonding ability of the 5′-uronamide is essential for the confor...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2748263/ https://ncbi.nlm.nih.gov/pubmed/18776545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nass/nrn326 |
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